在你问某人发生了什么事或遇到了什么问题的时候就可以说 "what's up?"。
- What's up? I came to your house to party and everybody is sitting around looking sad.
- What's up with Lauren? She's been acting in a very strange way.
值得注意的是，在美式英语里，"what’s up?" 是一个常见的打招呼用语，意思是"你好吗？"
- What's up, Frank? I haven't seen you in ages.
